보유모델
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모델 |
암종 |
Xenograft |
Syngeneic |
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Subcutaneous |
Bladder |
UM-UC-3 |
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Breast |
MCF7, MDA-MB-231 |
4T1, 4T1-Luc-TdTomato |
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Burkitt’s lymphoma |
Raji |
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Cervix |
A431, CaSki |
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Colon |
DLD-1, HCT-8, HCT-15, HCT-116, HT-29, LoVo, RKO, SW620 |
CT26, MC38 |
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Kidney |
SN12C |
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Leukemia |
K562 |
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Liver |
Hep3B, HepG2, HepG2-Red-Fluc, Huh7, Huh7-Luc, SK-Hep1 |
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Lung |
A549, H69, H146, H209, H460, H1299 |
LLC1 |
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Melanoma |
UACC-62 |
B16-F10 |
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Ovary |
OVCAR3, OVCAR-3-Luc, SKOV3, SNU251 |
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Pancreas |
AsPC-1, AsPC-1-Luc, BxPC-3, BxPC-3-Luc2, CaPan-1, MiaPaCa2, QGP1 |
PAN 02 | |
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Prostate |
DU145, PC3 |
TRAMP-C1 | |
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Stomach |
NCI-N87 |
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Orthotopic |
Breast |
4T1-Luc-TdTomato |
|
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Colon |
HCT116-Red, HT-29-Luc |
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Leukemia |
MOLM-13, MV4-11, Raji |
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Liver |
HepG2-Red-Fluc |
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Lung |
A549-Luc, NCI-H226-Luc, NCI-H1703-Luc |
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Ovary |
ES-2-Luc, OVCAR-3-Luc, SKOV3-Luc |
ID8-Luc |
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Pancreas |
AsPC-1-Luc, BxPC-3-Luc |
PAN02 |
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Prostate |
TRAMP-C1 |
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Metastasis |
Breast |
4T1-Luc-TdTomato (Intracardiac Injection), 4T1-Luc-TdTomato (Intravenous Injection) |
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Colon |
SW620-Luc |
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Leukemia |
WEHI-3 |
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Ovary |
ES-2-Luc (Orthotopic Injection), OVCAR-3-Luc (Intraperitoneal Injection), SK-OV-3-Luc (Intraperitoneal Injection) |
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Spontaneous Model |
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Lung |
Lung (Mutation: p53/ras) |
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Genetically Engineered Mouse |
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Lung |
Ba/F3/Her2 insertion cell line, EGFR mutant(L858R+T790M +C797S)-induced lung cancer in mouse |
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Humanized Mouse (hHSC) |
Endometrial |
Hec-1A subcutaneous xenograft, Ishikawa subcutaneous xenograft |
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Liver |
Hep3B-Luc orthotopic xenograft, Huh-7-Luc orthotopic xenograft, HepG2. 2.15 orthotopic xenograft |
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Ovary |
ES-2-Luc orthotopic xenograft, OVCA3-Luc orthotopic xenograft |
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Pancreas |
ASPC-1-Luc orthotopic xenograft, BxPC-3-Luc orthotopic xenograft |
서비스 내용
- 수요자 맞춤형 시험 디자인
- Tumor growth inhibition/delay 시험
- 단독 처리 (single treatment)
- 병용 처리 (combination treatment)
- Kaplan-Meier survival 시험
- Metastasis inhibition 시험
- Radiotherapy response 시험
- Histological analysis
- Tissue preparation, IHC, TUNEL, DNA/RNA/protein extraction 등
- Histopathology
- MOA & POC 검증
- In vivo imaging
- MRI, PET, PET-MR, CT, Optical imaging 활용 시험
- PD, tissue distribution
서비스 예시
대장암 subcutaneous xenograft model에서
in vivo 항암 효능 평가