온라인 문의 신청 제안서 > 항암유효성평가지원센터

Therapeutics

Cytotoxic drugs Immuno-oncology Targeted agents Oncolytic virus 기타

합성물질 천연물 단백질 유전자 세포 기타

Others

Biomarker Diagnostic panel

Brain Breast Cervix Cholangiocarcinoma Colon Esophagus Fibrosarcoma Head & neck Kidney Leukemia Liver Lung Melanoma Ovary Pancreas Prostate Stomach 기타 :

Target discovery Hit Lead Candidate Clinical trial

in vitro 유효성 평가

in vivo 유효성 평가

Toxicology PK/PD 기타

in vitro 유효성 평가

Cell viability / Death assay / IC₅₀ calculation / Synergy index in vitro tumorigenic potential Resistance Enzyme assay Signal pathway assay Histological analysis Organelle staining Biomarker assay MOA & POC verification Target enzyme-based screen Phenotype-based screen High throughput screen Organoid

in vivo 유효성 평가

Tumor growth inhibition Metastasis inhibition Immune cell infiltration Resistance Radiotherapy response Histological analysis MOA & POC verification Biomarker assay

Xenograft

세포주 환자유래

Subcutaneous xenograft Orthotopic xenograft Metastasis xenograft Patient-derived xenograft

Syngeneic

Subcutaneous syngeneic Orthotopic syngeneic Metastasis syngeneic Spontaneous syngeneic (GEM)

in vivo imaging

MRI PET/PET-MR CT Optical 기타

예비안전성평가

Target organ toxicity Cardiovascular toxicity Combined exploratory toxicity Tissue Cross Reactivity 기타

DMPK

in vitro ADME assay Cardiovascular toxicity Combined exploratory txicity Tissue Cross Reactivity 기타

자문

MRI PET/PET-MR CT Optical 기타