보유모델
|
모델 |
암종 |
세포주명 |
|
Subcutaneous Syngeneic Model |
Breast |
4T1 (BALB/c), 4T1-Luc-TdTomato (BALB/c) |
|
Colon |
CT26.WT (BALB/c), MC-38 (C57BL/6) |
|
|
Fibrosarcoma |
FSa-II (BALB/c) |
|
|
Lung |
LLC1 (C57BL/6) |
|
|
Melanoma |
B16/F10 (C57BL/6) |
|
|
Ovary |
ID8 (C57BL/6) |
|
|
Prostate |
TRAMP-C1 (C57BL/6) |
|
|
Orthotopic Syngeneic Model |
Breast |
4T1 (BALB/c), 4T1-Luc-TdTomato (BALB/c) |
|
Lung |
LLC1-Luc (C57BL/6) |
|
|
Prostate |
TRAMP-C1 (C57BL/6) |
|
|
Metastasis Syngeneic Model |
Breast |
4T1-Luc-TdTomato (Mammary Fat Pad Injection) 4T1-Luc-TdTomato (Intracardiac Injection) 4T1-Luc-TdTomato (Intravenous Injection) |
|
Leukemia |
WEHI-3 (Mouse Leukemia) |
|
|
Spontaneous Model (GEM) |
Lung |
Induced by p53/ras mutation |
|
Genetically Engineered Mouse (GEM) |
Immuno-Oncology |
CTLA-4 knock-out mouse, PD-1 knock-out mouse |
Others |
Asan NSG mouse |
서비스 내용
- 수요자 맞춤형 시험 디자인 (in vitro, in vivo, ex vivo)
- 마우스 모델을 이용한 Tumor growth inhibition/delay 시험
- 개발 약물의 단독 투여 및 기존 면역항암제 (ex. anti-PD-(L)1, anti-CTLA4 등)와의 병용 투여 효능 평가
- FACS를 이용한 tumor microenvironment 내의 면역세포 immunophenotyping Histological analysis (Tissue preparation, IHC, TUNEL)
- In vivo imaging
- Live animal IVIS imaging, MRI, PET, PET-MR, CT
- ADCC (Antibody-dependent cell mediated cytotoxicity), CDC (Complement dependent cytotoxicity) assay
- Treg (Regulatory T cell) suppression assay
- Metastasis inhibition assay
- Immuno-radiotherapy response assay
- Mouse tumor-infiltrated lymphocyte (TIL) analysis
- 사람 T세포 분석: MLR assay / CEFT assay /CMV Antigen Recall Assay
- PD-1:PD-L1 Inhibitor Screening Assay
서비스 예시
MC38 tumor 내의 tumor infiltrating lymphocytes 분석