보유모델
|
암종 |
세포주명 |
항암제 |
|
Colon |
COLO205 |
Selumetinib |
|
Leukemia |
MOLM-13 |
Azacitidine, Cytarabine,Decitabine,Quizartinib |
|
THP-1 |
Decitabine |
|
|
Lung |
A549 |
AUY922, Cisplatin, Gefitinib,Gemcitabine, Irradiation, Paclitaxel |
|
H209 |
Cisplatin, Etoposide |
|
|
H460 |
Cisplatin, Gemcitabine, Irradiation, Paclitaxel |
|
|
H1944 |
AUY922 |
|
|
H1975 |
AZD9291, WZ4002 |
|
|
H2228 |
Ceritinib/Lorlatinib, Crizotinib, TAE684, 17-DMAG |
|
|
H3122 |
Ceritinib/Lorlatinib, Crizotinib, 17-DMAG |
|
|
HCC827 |
Cisplatin, Erlotinib, Gefitinib, Paclitaxel, WZ4002 |
|
|
PC-9 |
AZD9291, Cisplatin, Erlotinib, Erlotinib/WZ4002, Gefitinib, Gefitinib/ WZ4002, Paclitaxel, WZ4002 |
|
|
기타 |
Ba/F3/AXL Ba/F3/del19 EGFR Ba/F3/del19+T790M+C797S Ba/F3/L858R Ba/F3/L858R+T790M+C797S |
Ba/F3/CCDC6-RET Ba/F3/del19+T790M Ba/F3/EML4-ALK Ba/F3/L858R+T790M Ba/F3/FLT3-ITD |
서비스 내용
-
Resistance cell line panels에서의 novel anti-cancer drug의 연구
- 내성 극복 여부 평가
- open-labeled global new drugs와의 스크리닝을 통한 비교
- Cell viability / Death assay / IC50 calculation
- In vivo TGI effects, Ex vivo screening
- Resistance 특이적 biomarkers 평가
- Pre-validated resistance candidate gene library
- MOA & POC 검증
- Effective combination strategy
- Cell viability between a novel drug and resistance candidate gene target drug
- Synergy index
- Validation of synergistic target gene
서비스 예시
Orthotopic xenograft model 활용
in vivo 내성 극복 여부 평가
Validation of drug efficacy by molecular analysis